5-Fluoroorotic acid Monohydrate
5-Fluoroorotic Acid
CAS: 703-95-7
Molecular Formula: C5H3FN2O4
5-Fluoroorotic acid Monohydrate - Names and Identifiers
| Name | 5-Fluoroorotic Acid |
| Synonyms | 5-FOA 5' FOA ro2-9945 nsc31712 Fluoroorotic acid 5-Fluoroorotic Acid 5-Fluoroorotic acid Monohydrate 5-FLUOROURACIL-4-CARBOXYLIC ACID 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid 5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid |
| CAS | 703-95-7 |
| EINECS | 211-876-0 |
| InChI | InChI=1/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12) |
| InChIKey | LODRRYMGPWQCTR-UHFFFAOYSA-N |
5-Fluoroorotic acid Monohydrate - Physico-chemical Properties
| Molecular Formula | C5H3FN2O4 |
| Molar Mass | 174.09 |
| Density | 1.6154 (estimate) |
| Melting Point | 278°C (dec.)(lit.) |
| Boling Point | 143°C (rough estimate) |
| Solubility | NH4OH 4 M: 50mg/mL, clear, faintly yellow |
| Merck | 14,4176 |
| pKa | 2.04±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.58 |
| MDL | MFCD00150658 |
| Physical and Chemical Properties | Light yellow crystals. Soluble in DMSO, slightly soluble in methanol, ethanol and other solvents. |
| Use | A research reagent used in genetic engineering |
5-Fluoroorotic acid Monohydrate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. |
| WGK Germany | 3 |
| RTECS | UV7800000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29335990 |
| Hazard Class | IRRITANT |
5-Fluoroorotic acid Monohydrate - Reference
| Reference Show more | 1. Fu Xiaomeng, xiaodongguang, Hao Aili, et al. Study on the tolerance of gis 1 gene to Saccharomyces cerevisiae [J]. China brewing 2018 037(005):48-53. 2. Chen Fazhong, Liao Dongqing, Li Xiaoming, etc. Construction of genetic engineering transformation system of Aspergillus oryzae AS3.800 [J]. Light Industry Technology, 2013, 26 (06):12-15. |
5-Fluoroorotic acid Monohydrate - Reference Information
| biological effects | 5-fluororotic acid is a fluorine-substituted derivative of orotic acid, a precursor of pyrimidine biosynthesis. 5-fluoro-orotic acid can be converted into toxic 5-fluorouracil by decarboxylase encoded by URA3 gene, so it is commonly used in gene screening of yeast. |
| Product Application | 5-fluoro-orotic Acid (5-FOA) reverse selection for yeast is a commonly used molecular genetic screening method. Yeast plasmid clearance, plasmid shuttling, allelic substitution and two-hybrid screening all used 5-FOA. 5-FOA itself is non-toxic to yeast cells, but the functional URA3 gene encodes orotic nucleoside -5 '-monophosphate decarboxylase (OMP decarboxylase), it is converted into a toxic form (e. G., 5-fluorouracil) so that yeast cells cannot grow. After screening, the yeast of the phenotype Ura was changed to the yeast of Ura-and 5-FOA(R). Product Application 1) detection of URA3 gene expression in yeast; 2) construction of yeast two-hybrid library; 3) other yeast genetics fields include gene replacement, mobile genetic factor analysis and gene mutation identification. Filter object sacacomyces cerevisiae, schosacomyces pombe, and other fungi species containing URA3 orthologs. |
| biological activity | 5-fluorotic is a selective agent in the molecular genetics of yeast. 5-fluorotic has an anti-cancer effect close to that of 5-fluorocytosine and a moderate anti-Dermatophyte effect. |
| Use | A Research reagent for genetic engineering |
Last Update：2024-04-09 20:52:54
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